Helping The others Realize The Advantages Of ceesdekker
Helping The others Realize The Advantages Of ceesdekker
Blog Article
In case you discover any main omissions or other inaccuracies within the publication list, please let's know.
Human Rad51 filaments on double- and single-stranded DNA: correlating standard and irregular forms with recombination operate.
Multicolor imaging from the bacterial nucleoid and cell division proteins with blue, orange, and in the vicinity of-infrared fluorescent proteins
Considering that 2000, Dekker has shifted the main target of his do the job in the direction of biophysics the place he experiments the Qualities of solitary biomolecules and cells utilizing the applications of nanotechnology. This transformation of discipline was pushed by his fascination with the remarkable working of biological molecular constructions, and from the extended-term viewpoint that lots of appealing discoveries can be expected On this discipline.[five] Latest strains of investigate in his biophysics team are in the areas of:[6]
That could be a dream of mine and we established to operate that has a scrumptious dose of naivety. This is certainly a thing that will probably produce amazing leads to the extended time period, but that does not issue. You shouldn't only want to operate around the issues of tomorrow, but also within the issues of your day right after tomorrow.’
Experimental period diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
What distinguishes biology from chemistry is that these parts together make up a residing system. The key of said daily life, I think, lies while in the interactions, the interaction of People molecules. The massive issue about the origin ceesdekker.net of daily life continues to be unanswered. How did we at any time evolve from easy molecules in the extremely intricate systems we see right now? We do not know. I want to work on These types of significant, open inquiries.’
Nanopores represent an elegant and versatile Instrument to measure single molecules. We research novel detection modes with solid-state nanopores as well as a variety of strategies to measure proteins with nanopores. Assignments encompass the next:
2003, demonstrated the very first biosensors produced out of a carbon nanotube; fixed the composition and system of DNA fix proteins; and discovery of a fresh method for fabricating solid-point out nanopores for DNA translocation
one). The current–voltage curves confirmed significant modulations with gate voltage, even at place temperature, which was in line with band bending inside of a ~0.6 eV bandgap semiconducting nanotube. These facts also showed the conductance might be modulated by 6 orders of magnitude by changing the gate voltage. The outcome of the perform — a home-temperature transistor created from only one carbon nanotube molecule — had been released in Nature in May possibly 1998.
Example (four) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is proven in grey, the rim of your pore is highlighted in pink, plus a 3D rendering in the motion of your DNA rod is exhibited.
2001, discovery of solitary-electron transistors at area temperature determined by nanotubes; realization of initially logic circuits with carbon nanotube equipment; and discovery of your molecular composition of DNA repair enzymes with AFM
2008, to start with observation of protein-coated DNA translocation as a result of nanopores; fixed the origin of your electrophoretic drive on DNA in nanopores; found out an important velocity raise of microtubules in electric powered fields; learned an anomalous electro-hydrodynamic orientation of microtubules; and solved the origin of sound in carbon nanotubes in liquid
Instance (two) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is revealed in grey, the rim with the pore is highlighted in crimson, in addition to a 3D rendering in the movement in the DNA rod is exhibited.